翻訳と辞書 Words near each other ・ Origin of the Moon ・ Origin of the name "Empire State" ・ Origin of the name Kainuu ・ Origin of the name Khuzestan ・ Origin of the name Kven ・ Origin of the Oak Ridges Moraine ・ Origin of the Romanians ・ Origin of the Storm (album) ・ Origin of the Western Ganga Dynasty ・ Origin of the World ・ Origin of transfer ・ Origin of Vijayanagara Empire ・ Origin of water on Earth ・ Origin Pacific Airways ・ Origin PC ・ Origin recognition complex ・ Origin Records ・ Origin Scotland ・ Origin South Africa ・ Origin story ・ Origin Systems ・ Origin theories of Christopher Columbus ・ Origin Vol. 1 ・ Origin-of-death myth ・ Origin8Media ・ Originair ・ Original (Cir.Cuz song) ・ Original (disambiguation) ・ Original (film) ・ Original (Leftfield song) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Origin recognition complex ： ウィキペディア英語版 Origin recognition complex In molecular biology, origin recognition complex (ORC) is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes in an ATP-dependent manner to origins of replication. The subunits of this complex are encoded by the ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6 genes. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle. ORC directs DNA replication throughout the genome and is required for its initiation. ORC bound at replication origins serves as the foundation for assembly of the pre-replication complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-Mcm7 complex. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase. Cell cycle-regulated phosphorylation of Orc2, Orc6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase.〔 In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR).〔〔〔 ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers.〔 Both Orc1 and Orc5 bind ATP, though only Orc1 has ATPase activity. The binding of ATP by Orc1 is required for ORC binding to DNA and is essential for cell viability.〔 The ATPase activity of Orc1 is involved in formation of the pre-RC. ATP binding by Orc5 is crucial for the stability of ORC as a whole. Only the Orc1-5 subunits are required for origin binding; Orc6 is essential for maintenance of pre-RCs once formed. Interactions within ORC suggest that Orc2-3-6 may form a core complex.〔 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Origin recognition complex」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.